Extensive perivascular spaces burden causally affects neurodegenerative diseases and brain structure: A two-sample bidirectional Mendelian randomization study
Our study provides evidence for the causal associations of different extensive PVS burden phenotypes with neurodegenerative diseases and brain structures, improving our understanding of the complex relationships between different brain injuries.
Authors
- Chang Xu (ORCID: https://orcid.org/0000-0002-1572-9895)
- Wenxian Sun
- Pei Wang (ORCID: https://orcid.org/0000-0002-1650-3353)
- Jin Gong (ORCID: https://orcid.org/0000-0002-0059-8087)
- Runqi Chen
- Heya Luan
- Cuibai Wei
- S. Li
- Xiaodong Han
Institutions
- Capital Medical University (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- National Clinical Research (US)
- Changchun University of Chinese Medicine (CN)
- Beihang University (CN)
Publication Details
- Journal
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Published
- 2025-02-06
- DOI
- https://doi.org/10.1016/j.pnpbp.2025.111284
- Citations
- 3
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 2.73