How to Study the Effects of Dietary Lipids on the Small Intestinal Microbiome? Methodological Design and Evaluation of the Human HealThy fAt, haPpy mIcRobiome (TAPIR) Proof-of-Concept Study
The dietary intervention was successful and well-tolerated. We sampled in the small intestine with capsules and catheters, each with its own (dis)advantages. The comprehensive description and evaluation of our study execution offer practical insights supporting future study designs in food-microbe interactions in the small intestine.The trial is registered at clinicaltrials.gov as NCT06064266.
Authors
- Nicole de Wit (ORCID: https://orcid.org/0000-0002-6686-8836)
- Lonneke JanssenDuijghuijsen (ORCID: https://orcid.org/0000-0002-9516-6681)
- Corine Perenboom
- Guido Hooiveld (ORCID: https://orcid.org/0000-0003-1954-3542)
- Katrien Fransen (ORCID: https://orcid.org/0000-0003-2127-4599)
- Ruzhi Deng (ORCID: https://orcid.org/0000-0002-4587-7223)
- Mara van Trijp
Institutions
- Wageningen University & Research (NL)
Publication Details
- Journal
- Current Developments in Nutrition
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1016/j.cdnut.2025.104564
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministerie van Economische Zaken en Klimaat
- Topconsortium voor Kennis en Innovatie