CD4 <sup>+</sup> T Cells Expressing Viral Proteins Induce HIV-Associated Endothelial Dysfunction and Hypertension Through Interleukin 1α–Mediated Increases in Endothelial NADPH Oxidase 1
We provide the first evidence that CD4<sup>+</sup> T cells expressing HIV viral proteins induced hypertension through IL-1α-mediated increases in vascular NOX1, which impairs endothelial function in males and females.
Authors
- Thiago Bruder‐Nascimento (ORCID: https://orcid.org/0000-0001-5671-318X)
- Vijay Patel (ORCID: https://orcid.org/0000-0002-8402-2682)
- Candee T. Barris (ORCID: https://orcid.org/0000-0001-5313-6487)
- Simone Kennard (ORCID: https://orcid.org/0000-0002-7564-9192)
- Taylor C. Kress (ORCID: https://orcid.org/0000-0003-2615-3788)
- Eric J. Belin de Chantemèle (ORCID: https://orcid.org/0000-0002-0184-3830)
- David W. Stepp (ORCID: https://orcid.org/0000-0003-0184-8321)
- Jie Chen (ORCID: https://orcid.org/0000-0003-2151-5276)
- Coleton Jordan
- Rodger D. MacArthur (ORCID: https://orcid.org/0009-0000-8836-0083)
- Rafał Pacholczyk (ORCID: https://orcid.org/0000-0002-9629-4829)
- Beryl Khakina (ORCID: https://orcid.org/0009-0003-0792-6498)
- László Kovács (ORCID: https://orcid.org/0000-0002-9886-6755)
Institutions
- Augusta University (US)
- Norwegian Womens Public Health Association (NO)
- University of South Alabama (US)
Publication Details
- Journal
- Circulation
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1161/circulationaha.124.070538
- Citations
- 8
- Primary Topic
- HIV-related health complications and treatments
- Type
- article
- Field-Weighted Citation Impact
- 18.03