Metformin Ameliorates Ulcerative Colitis Through Inhibiting NLRP3 Inflammasome Activation
Met significantly ameliorated UC by inhibiting NLRP3 inflammasome activation in macrophages. The underlying mechanisms not only involved the inhibition of NF-κB signaling pathway activation (first signal), but was also associated with up-regulation of UCP2 and NCF1 levels and thus the repression of ROS generation (second signal).
Authors
- Xinyu Huang (ORCID: https://orcid.org/0000-0002-9380-3026)
- Chaofang Zhang
- Yuanfang Ma (ORCID: https://orcid.org/0000-0001-5635-2660)
- Run Cao (ORCID: https://orcid.org/0000-0002-5759-102X)
- Wenqing Qi
- Yuting Ma (ORCID: https://orcid.org/0000-0001-6267-1852)
- Hailong Zhang (ORCID: https://orcid.org/0000-0003-3316-4290)
- Jing Jing (ORCID: https://orcid.org/0000-0001-9822-5758)
- Jiayi He (ORCID: https://orcid.org/0000-0002-2267-3666)
- Guiling Wang
- Zheng Lu
Institutions
- Xuzhou Central Hospital (CN)
- First Affiliated Hospital of Henan University (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-02-01
- DOI
- https://doi.org/10.2147/jir.s503033
- Citations
- 3
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.42