Genetic associations with measles PRNT and IgG antibody response to MMR vaccination in 6- and 15-month-old children
In an MMR vaccine trial, this study identified novel genetic regions on chromosomes 1 and 9 associated with measles PRNT in healthy infants. Four-digit HLA types were associated with both Measles IgG and PRNT. Associations between SNPs and HLA have been investigated previously, and we suspect the difference in results is due to dissimilarities between cohorts and study design, especially regarding participants' age and time from immunization to immune outcome measurement.
Authors
- Jesper Kiehn Sørensen (ORCID: https://orcid.org/0000-0001-7735-4622)
- Jannet Svensson (ORCID: https://orcid.org/0000-0002-9365-0728)
- Se Jun Kim (ORCID: https://orcid.org/0000-0001-7150-4685)
- Michelle Malon (ORCID: https://orcid.org/0000-0002-2436-4293)
- Lone Graff Stensballe (ORCID: https://orcid.org/0000-0003-1569-153X)
- Flemming Pociot (ORCID: https://orcid.org/0000-0003-3274-5448)
- Andreas Jensen (ORCID: https://orcid.org/0000-0003-4302-2982)
- Dorthe Maria Vittrup
- Jonas Bybjerg‐Grauholm (ORCID: https://orcid.org/0000-0003-1705-4008)
- Anne Cathrine Zimakoff (ORCID: https://orcid.org/0000-0001-9872-6608)
- Simranjeet Kaur (ORCID: https://orcid.org/0009-0008-9213-8328)
- Emma Victoria Hatley
Institutions
- Statens Serum Institut (DK)
- Steno Diabetes Centers (DK)
- Herlev Hospital (DK)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
Publication Details
- Journal
- Vaccine
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1016/j.vaccine.2025.126788
- Citations
- 2
- Primary Topic
- Virology and Viral Diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- Dagmar Marshalls Fond
- Innovationsfonden
- Hans og Nora Buchards Fond
- Kong Christian den Tiendes Fond
- Ville Heises Legat