Fixed-Duration Acalabrutinib Combinations in Untreated Chronic Lymphocytic Leukemia
Acalabrutinib-venetoclax with or without obinutuzumab significantly prolonged progression-free survival as compared with chemoimmunotherapy in fit patients with previously untreated CLL. (Funded by AstraZeneca; AMPLIFY ClinicalTrials.gov number, NCT03836261.).
Authors
- Miguel Arturo Pavlovsky (ORCID: https://orcid.org/0000-0003-4561-3153)
- Alessandra Tedeschi (ORCID: https://orcid.org/0000-0001-8724-2771)
- Alan P Skarbnik (ORCID: https://orcid.org/0000-0002-1276-7546)
- Árpád Illés (ORCID: https://orcid.org/0000-0001-6548-2926)
- Andrew Aw (ORCID: https://orcid.org/0000-0002-5043-0557)
- Jennifer R. Brown (ORCID: https://orcid.org/0000-0003-2040-4961)
- Marianne de Borja
- Veerendra Munugalavadla (ORCID: https://orcid.org/0000-0002-2390-3822)
- Carolyn Owen (ORCID: https://orcid.org/0000-0003-4110-1708)
- Małgorzata Wach
- Arnon Philip Kater (ORCID: https://orcid.org/0000-0003-3190-1891)
- Daniel Lysák (ORCID: https://orcid.org/0000-0001-9391-4247)
- Martin Šimkovič (ORCID: https://orcid.org/0000-0003-0331-5334)
- John Francis Seymour (ORCID: https://orcid.org/0000-0003-2188-6835)
- Kara Miller
- Paolo Ghia (ORCID: https://orcid.org/0000-0003-3750-7342)
- Wojciech J. Jurczak (ORCID: https://orcid.org/0000-0003-1879-8084)
- Ting Yu
- Ki-Seong Eom
- Barbara Eichhorst
Institutions
- Medical University of Lublin (PL)
- The Royal Melbourne Hospital (AU)
- University of Debrecen (HU)
- University of Ottawa (CA)
- Vita-Salute San Raffaele University (IT)
- The University of Melbourne (AU)
- University of Calgary (CA)
- Charles University (CZ)
- Peter MacCallum Cancer Centre (AU)
- Novant Health (US)
- Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda (IT)
- University Hospital Plzen (CZ)
- Dana-Farber Cancer Institute (US)
- IRCCS Ospedale San Raffaele (IT)
- University Hospital Hradec Králové (CZ)
- AstraZeneca (Canada) (CA)
- AstraZeneca (United States) (US)
- The Maria Sklodowska-Curie National Research Institute of Oncology (PL)
- St. Paul's Hospital (KR)
- Amsterdam University Medical Centers (NL)
- University Hospital Cologne (DE)
- The Catholic University of Korea Seoul St. Mary's Hospital (KR)
- Catholic University of Korea (KR)
- University of Amsterdam (NL)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1056/nejmoa2409804
- Citations
- 76
- Primary Topic
- Chronic Lymphocytic Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 123.53
Funders
- AstraZeneca