CD4+ T-Cell Lymphoma Harboring a Chimeric Antigen Receptor Integration in <i>TP53</i>
Malignant T-cell transformation after chimeric antigen receptor (CAR) T-cell therapy has been described, but the contribution of CAR integration to oncogenesis is not clear. Here we report a case of a T-cell lymphoma harboring a lentiviral integration in a known tumor suppressor, <i>TP53</i>, which developed in a patient with multiple myeloma after B-cell maturation antigen (BCMA) CAR T-cell therapy.
Authors
- Saad Z. Usmani (ORCID: https://orcid.org/0000-0002-5484-8731)
- Sneha Mitra (ORCID: https://orcid.org/0000-0002-7718-8721)
- J.K. Everett (ORCID: https://orcid.org/0000-0002-9200-9322)
- Frederic D. Bushman (ORCID: https://orcid.org/0000-0003-4740-4056)
- Gunjan L. Shah (ORCID: https://orcid.org/0000-0002-9977-0456)
- Özgür Can Eren (ORCID: https://orcid.org/0000-0001-9889-2702)
- Ahmet Doǧan (ORCID: https://orcid.org/0000-0001-6576-5256)
- Karlo Perica (ORCID: https://orcid.org/0000-0002-3595-7596)
- Utsav Patel
- Nicholas D. Socci (ORCID: https://orcid.org/0000-0002-8254-6925)
- Michael Scordo (ORCID: https://orcid.org/0000-0002-9484-0240)
- Ruchi Patel (ORCID: https://orcid.org/0000-0001-9090-8423)
- Maria E. Arcila (ORCID: https://orcid.org/0000-0001-5824-6554)
- Sham Mailankody (ORCID: https://orcid.org/0000-0002-2815-9561)
- Steven M. Horwitz (ORCID: https://orcid.org/0000-0002-6399-2006)
- Sergio A. Giralt (ORCID: https://orcid.org/0000-0003-1944-5053)
- Aoife M. Roche
- Laetitia Borsu (ORCID: https://orcid.org/0000-0003-1603-630X)
- Dylan Domenico (ORCID: https://orcid.org/0000-0002-6041-5078)
- Elli Papaemmanuil (ORCID: https://orcid.org/0000-0003-1709-8983)
- Gunes Gundem (ORCID: https://orcid.org/0000-0002-0070-9859)
- Christina C. Leslie
- Angelina Petrichenko (ORCID: https://orcid.org/0000-0003-0600-0709)
- Nayan Jain (ORCID: https://orcid.org/0000-0002-3831-2136)
- Jae H. Park (ORCID: https://orcid.org/0000-0002-2903-5130)
- Michel Sadelain
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- Cornell University (US)
- Molecular Oncology (United States) (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1056/nejmoa2411507
- Citations
- 58
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 60.63
Funders
- Leukemia and Lymphoma Society
- University of Pennsylvania
- Memorial Sloan-Kettering Cancer Center
- National Institutes of Health
- Center for AIDS Research, University of Washington
- National Cancer Institute