Post‐selection inference for the Cox model with interval‐censored data

We develop a post-selection inference method for the Cox proportional hazards model with interval-censored data, which provides asymptotically valid p-values and confidence intervals conditional on the model selected by lasso. The method is based on a pivotal quantity that is shown to converge to a uniform distribution under local parameters. Our method involves estimation of the efficient information matrix, for which several approaches are proposed with proof of their consistency. Thorough simulation studies show that our method has satisfactory performance in samples of modest sizes. The utility of the method is illustrated via an application to an Alzheimer's disease study.

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Publication Details

Journal
Scandinavian Journal of Statistics
Published
2025-02-05
DOI
https://doi.org/10.1111/sjos.12768
Citations
1
Primary Topic
Statistical Methods and Inference
Type
article
Field-Weighted Citation Impact
2.63

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article

Post‐selection inference for the Cox model with interval‐censored data

Haolei Weng, Jianrui Zhang, Chenxi Li
1 citations
Scandinavian Journal of Statistics
Statistical Methods and Inference
2.63
article

Post‐selection inference for the Cox model with interval‐censored data

Haolei Weng, Jianrui Zhang, Chenxi Li
article en
1 citations

Abstract

We develop a post-selection inference method for the Cox proportional hazards model with interval-censored data, which provides asymptotically valid p-values and confidence intervals conditional on the model selected by lasso. The method is based on a pivotal quantity that is shown to converge to a uniform distribution under local parameters. Our method involves estimation of the efficient information matrix, for which several approaches are proposed with proof of their consistency. Thorough simulation studies show that our method has satisfactory performance in samples of modest sizes. The utility of the method is illustrated via an application to an Alzheimer's disease study.

Scandinavian Journal of StatisticsVol. 52(2)
Michigan State University (US)
National Science Foundation, Alzheimer's Disease Neuroimaging Initiative, National Institutes of Health, National Science Foundation of Sri Lanka
Openalex Percentile: Top 15%
Statistical Methods and Inference
2.63
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