Emodin protects against severe acute pancreatitis-associated acute lung injury by activating Nrf2/HO-1/GPX4 signal and inhibiting ferroptosis in vivo and in vitro
Our results demonstrated that EMO effectively inhibited ferroptosis both in vivo and in vitro, while also modulating the Nrf2/HO-1/GPX4 signaling pathway to provide protection against SAP-ALI.
Authors
- Xuanchi Dong (ORCID: https://orcid.org/0000-0003-2894-4778)
- Haiyun Wen (ORCID: https://orcid.org/0000-0001-8390-0343)
- Yalan Luo (ORCID: https://orcid.org/0000-0002-9619-5468)
- Bowen Lan
- Hailong Chen (ORCID: https://orcid.org/0000-0002-1101-1990)
- Huijuan Li (ORCID: https://orcid.org/0009-0004-3198-9971)
- Xuetao Zhang (ORCID: https://orcid.org/0000-0002-8485-8818)
- Gang Shen (ORCID: https://orcid.org/0000-0001-6845-2191)
- Peng Ge (ORCID: https://orcid.org/0000-0002-2647-2474)
Institutions
- Dalian Medical University (CN)
- First Affiliated Hospital of Dalian Medical University (CN)
Publication Details
- Journal
- BMC Gastroenterology
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1186/s12876-025-03660-1
- Citations
- 9
- Primary Topic
- Optimism, Hope, and Well-being
- Type
- article
- Field-Weighted Citation Impact
- 13.90
Funders
- National Natural Science Foundation of China