Eltrombopag-Induced Falsely Elevated Bilirubin Concentrations in Enzymatic and Vanadate Oxidation Assays: Involvement of High Serum Eltrombopag Concentrations
Eltrombopag causes clinically significant concentration-dependent interference in total blood bilirubin, but not in conjugated bilirubin measurements through the enzymatic assay in patients with aplastic anemia. The vanadate oxidation assay may be used as an alternative to measure total blood bilirubin when the eltrombopag concentration is below 50 mcg/mL.
Authors
- Seiji Oda
- Shigeru Chiba (ORCID: https://orcid.org/0000-0001-9458-5713)
- Kosuke Doki (ORCID: https://orcid.org/0000-0003-2497-0063)
- Naoshi Obara (ORCID: https://orcid.org/0000-0001-6563-3093)
- Yoshiharu Suzuki (ORCID: https://orcid.org/0000-0002-6250-1252)
- Masato Homma (ORCID: https://orcid.org/0000-0002-4824-3242)
Institutions
- University of Tsukuba (JP)
- Mito Saiseikai General Hospital (JP)
- University of Tsukuba Hospital (JP)
Publication Details
- Journal
- Therapeutic Drug Monitoring
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1097/ftd.0000000000001307
- Primary Topic
- Blood groups and transfusion
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science