High prevalence of FAP+ cancer-associated fibroblasts predicts poor outcome in patients with high-grade serous ovarian cancer with high CD8 T-cell density
The TME infiltration of FAP-positive fibroblasts is associated with poor prognosis in HGSC with high CD8+ cells density. Targeting the FAP+ subset of fibroblasts may unlock the local immune-activation in the TME thus enhance the positive prognostic effect of T-cells in ovarian cancer.
Authors
- Hanna Dahlstrand (ORCID: https://orcid.org/0000-0002-6166-3532)
- Päivi Kannisto (ORCID: https://orcid.org/0000-0002-5517-1494)
- Josefin Severin Karlsson
- Ingrid Hedenfalk (ORCID: https://orcid.org/0000-0002-6840-3397)
- Sofia Westbom-Fremer (ORCID: https://orcid.org/0000-0002-4365-371X)
- Alfonso Martín-Bernabé (ORCID: https://orcid.org/0000-0002-8885-6043)
- Sara Corvigno (ORCID: https://orcid.org/0000-0001-5458-2243)
- Laura Martín de la Fuente (ORCID: https://orcid.org/0000-0002-3618-8282)
- Arne Östman (ORCID: https://orcid.org/0000-0003-3993-0021)
- Joseph W. Carlson (ORCID: https://orcid.org/0000-0002-3006-4107)
- Christian Klein (ORCID: https://orcid.org/0000-0001-7594-7280)
- Susanne Malander (ORCID: https://orcid.org/0000-0002-4059-1349)
- Artur Mezheieusky
- Josefin Fernebro
Institutions
- Hebron University (PS)
- Karolinska University Hospital (SE)
- Lund University (SE)
- Zurich Insurance Group (Switzerland) (CH)
- Karolinska Institutet (SE)
- Skåne University Hospital (SE)
Publication Details
- Journal
- Gynecologic Oncology
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1016/j.ygyno.2025.01.010
- Citations
- 9
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 9.41
Funders
- Cancerfonden
- Stockholms Läns Landsting
- Radiumhemmets Forskningsfonder