Effect of Low-Dose Ketamine Infusion in the Intensive Care Unit on Postoperative Opioid Consumption and Traumatic Memories After Hospital Discharge: A Randomized Controlled Trial
Low-dose ketamine is associated with a small but statistically significant reduction (15%) of postoperative opioid consumption in the ICU. Our secondary study revealed that patients who received low-dose ketamine during fentanyl-based postoperative pain therapy in the ICU recalled more frightening and delusional memories after ICU discharge.
Authors
- Onuma Chaiwat (ORCID: https://orcid.org/0000-0001-5407-306X)
- Nattachai Hemtanon (ORCID: https://orcid.org/0009-0001-0382-6401)
- Napat Thikom
- Annop Piriyapatsom (ORCID: https://orcid.org/0000-0001-7372-3240)
- Karuna Wongtangman (ORCID: https://orcid.org/0000-0003-2444-8275)
- Nattaya Raykateeraroj (ORCID: https://orcid.org/0000-0002-1212-2115)
- Nuanprae Kitisin (ORCID: https://orcid.org/0000-0001-9703-3551)
- Omid Azimaraghi (ORCID: https://orcid.org/0000-0001-8367-741X)
- Matthias Eikermann (ORCID: https://orcid.org/0000-0002-7893-0596)
- Piyawuth Kamtip
Institutions
- Albert Einstein College of Medicine (US)
- Siriraj Hospital (TH)
- Montefiore Medical Center (US)
- Mahidol University (TH)
- University of Duisburg-Essen (DE)
Publication Details
- Journal
- Anesthesia & Analgesia
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1213/ane.0000000000007419
- Citations
- 10
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 15.45