Inhibition of LRRK2 Ameliorates <i>Aspergillus fumigatus</i> Keratitis by Regulating STING Signaling Pathways
LRRK2 inhibition ameliorates A. fumigatus-induced inflammation through modulating STING signaling pathways in both HCECs and mouse models. Our results suggest that targeted inhibition of LRRK2 could be a promising strategy for FK treatment.
Authors
- Fang Han (ORCID: https://orcid.org/0000-0002-8743-8763)
- Hui Guo (ORCID: https://orcid.org/0000-0003-3901-6336)
- Jiayin Wu (ORCID: https://orcid.org/0000-0002-7937-478X)
- Lin Shen (ORCID: https://orcid.org/0000-0003-1134-2922)
- Leyi Wang (ORCID: https://orcid.org/0000-0002-1726-5342)
- Jianqiao Li (ORCID: https://orcid.org/0000-0001-6145-424X)
- Yangyang Li (ORCID: https://orcid.org/0009-0003-2578-856X)
Institutions
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1167/iovs.66.2.13
- Citations
- 2
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- Wayne State University
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province