Ferula sesquiterpenes, ferutinin, galbanic acid and karatavic acid, suppress thymocyte volume regulation and proliferation by blocking the volume-sensitive anion channel
The VSOR/VRAC channel blockage by Ferula sesquiterpenes was found to impair the CVR machinery of thymocytes, resulting in suppression of cell proliferation. The necrotic cell death is not a direct consequence of VSOR/VRAC and RVD inhibition, likely involving other cellular pathways.
Authors
- S. I. Rustamova (ORCID: https://orcid.org/0000-0001-5747-2891)
- Petr G. Merzlyak (ORCID: https://orcid.org/0000-0002-7733-7598)
- Ravshan Z. Sabirov
- Nargiza A. Tsiferova
- Gulnoza A. Toshtemirova
- Ranokhon Sh. Kurbannazarova (ORCID: https://orcid.org/0000-0003-3819-910X)
- В. Н. Сыров
- Diyor D. Fayziev (ORCID: https://orcid.org/0000-0002-2832-7625)
- Sirojbek A Khojiboev
- Utkir K Inogamov
Institutions
- Yunusov Institute of the Chemistry of Plant Substances (UZ)
- National University of Uzbekistan (UZ)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1016/j.biopha.2025.117875
- Citations
- 3
- Primary Topic
- Genomics, phytochemicals, and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 2.42