jax-smfsb: A Python library for stochastic systems biology modelling and inference

Many biological processes, and especially molecular biochemical processes, exhibit non-trivial stochasticity in their dynamical behaviour (Wilkinson, 2009).The popular textbook Stochastic modelling for systems biology, third edition (Wilkinson, 2018) describes the stochastic approach to modelling and simulation of biochemical processes, and how to do Bayesian inference for the parameters of such models using time course data (Golightly & Wilkinson, 2011).jax-smfsb provides a fast and efficient implementation of all of the algorithms described in Wilkinson ( 2018), able to effectively exploit multiple cores and GPUs, leading to performance suitable for the analysis of non-trivial research problems.

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Publication Details

Journal
The Journal of Open Source Software
Published
2025-02-05
DOI
https://doi.org/10.21105/joss.07491
Primary Topic
Gene Regulatory Network Analysis
Type
article
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article

jax-smfsb: A Python library for stochastic systems biology modelling and inference

Darren J. Wilkinson
The Journal of Open Source Software
Gene Regulatory Network Analysis
article

jax-smfsb: A Python library for stochastic systems biology modelling and inference

Darren J. Wilkinson
article en

Abstract

Many biological processes, and especially molecular biochemical processes, exhibit non-trivial stochasticity in their dynamical behaviour (Wilkinson, 2009).The popular textbook Stochastic modelling for systems biology, third edition (Wilkinson, 2018) describes the stochastic approach to modelling and simulation of biochemical processes, and how to do Bayesian inference for the parameters of such models using time course data (Golightly & Wilkinson, 2011).jax-smfsb provides a fast and efficient implementation of all of the algorithms described in Wilkinson ( 2018), able to effectively exploit multiple cores and GPUs, leading to performance suitable for the analysis of non-trivial research problems.

The Journal of Open Source SoftwareVol. 10(106)
Durham University (GB)
Openalex Percentile: Top 98%
Gene Regulatory Network Analysis
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