Single Intraluminal Delivery of a Nitric Oxide-Donor Results in Inhibition of Intimal Thickening in the Rabbit Femoral Artery
Simultaneous angioplasty of the rabbit iliac artery and direct injection of linsidomine into the vessel wall seem to be an effective strategy to reduce neointima formation. Similar, local application of liposome encapsulation of human nitric oxide synthase-2 transfection resulted in potent inhibition of intima proliferation and SMC proliferation due to local restoration NO within the injured vasculature.
Authors
- Tilo Großer (ORCID: https://orcid.org/0000-0001-8569-8396)
- Karl Werdan (ORCID: https://orcid.org/0000-0001-8137-2938)
- Harald Darius
- Michael Buerke (ORCID: https://orcid.org/0009-0009-5477-9957)
- Waltraut Ibe
- Priyanka Böttger
- Hansjörg Schwertz (ORCID: https://orcid.org/0000-0002-0597-8206)
- Stephan Lindemann
- Jean‐Paul Boissel
Institutions
- Johannes Gutenberg University Mainz (DE)
- Martin Luther University Halle-Wittenberg (DE)
- University of Pennsylvania (US)
Publication Details
- Journal
- Journal of Vascular Research
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1159/000544029
- Primary Topic
- Cardiovascular and exercise physiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00