Decreased neutrophil-to-lymphocyte ratio predicted cognitive improvement in late-life depression treated with vortioxetine: Findings from an eight-week randomized controlled trial

Vortioxetine treatment was associated with decreased NLR levels in late-life depression, and reductions in NLR predicted improvements in cognitive function and depressive symptoms, suggesting a potential link between inflammation and clinical outcomes.

Authors

E. Thomas Lewis
Dag Aarsland (ORCID: https://orcid.org/0000-0001-6314-216X)
Allan H. Young (ORCID: https://orcid.org/0000-0003-2291-6952)
Lingfeng Xue (ORCID: https://orcid.org/0000-0002-9922-5554)
Mariia Bocharova (ORCID: https://orcid.org/0000-0002-2113-699X)

Institutions

King's College London (GB)

Publication Details

Journal: Brain Behavior and Immunity
Published: 2025-02-05
DOI: https://doi.org/10.1016/j.bbi.2025.01.029
Citations: 8
Primary Topic: Tryptophan and brain disorders
Type: article
Field-Weighted Citation Impact: 4.62

Controls

|||

ALL TIME

JAN

FEB

MAR

APR

MAY

JUN

JUL

AUG

SEP

OCT

article

Decreased neutrophil-to-lymphocyte ratio predicted cognitive improvement in late-life depression treated with vortioxetine: Findings from an eight-week randomized controlled trial

E. Thomas Lewis, Dag Aarsland, Allan H. Young, Lingfeng Xue et al.

Feb 5, 2025

8 citations

Brain Behavior and Immunity

Tryptophan and brain disorders

4.62

article

Decreased neutrophil-to-lymphocyte ratio predicted cognitive improvement in late-life depression treated with vortioxetine: Findings from an eight-week randomized controlled trial

E. Thomas Lewis, Dag Aarsland, Allan H. Young, Lingfeng Xue, Mariia Bocharova

February 5, 2025article en

8 citations

Abstract

Vortioxetine treatment was associated with decreased NLR levels in late-life depression, and reductions in NLR predicted improvements in cognitive function and depressive symptoms, suggesting a potential link between inflammation and clinical outcomes.

Brain Behavior and ImmunityVol. 126

King's College London (GB)

Zero hunger

Openalex Percentile: Top 5%

Tryptophan and brain disorders

4.62

DOI Open Access PDF OpenAlex

AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Decreased neutrophil-to-lymphocyte ratio predicted cognitive improvement in late-life depression treated with vortioxetine: Findings from an eight-week randomized controlled trial — E. Thomas Lewis, Dag Aarsland, et al. · Brain Behavior and Immunity (2025) | TGRS Research Map | TGRS