Folic acid supplementation in children with sickle cell disease: a randomized double-blind noninferiority cross-over trial
Despite mandatory food fortification and advances in the medical treatment of SCD, it appears that some children with this condition may still benefit from daily folic acid supplementation. Whether this translates to improved clinical outcomes remains uncertain. This trial was registered at clinicaltrials.gov as NCT04011345 (https://clinicaltrials.gov/study/NCT04011345).
Authors
- Angela M. Devlin (ORCID: https://orcid.org/0000-0002-1390-6587)
- Crystal D Karakochuk (ORCID: https://orcid.org/0000-0002-1025-2194)
- Joel Singer (ORCID: https://orcid.org/0000-0003-4936-4086)
- Brock A. Williams (ORCID: https://orcid.org/0000-0003-3239-2697)
- John K. Wu (ORCID: https://orcid.org/0000-0002-6002-4878)
- Ali Amid (ORCID: https://orcid.org/0000-0001-6926-7502)
- Heather McCartney (ORCID: https://orcid.org/0000-0002-4728-0308)
- Suzanne Vercauteren (ORCID: https://orcid.org/0000-0003-2224-0307)
Institutions
- University of British Columbia (CA)
- St. Paul's Hospital (CA)
- Centre for Advancing Health Outcomes (CA)
- St. Paul's Hospital (CA)
- BC Children's Hospital (CA)
Publication Details
- Journal
- American Journal of Clinical Nutrition
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1016/j.ajcnut.2025.02.001
- Citations
- 1
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- Thrasher Research Fund
- BC Children's Hospital
- Canadian Institutes of Health Research