HIV-1 envelope diversity and sensitivity to broadly neutralizing antibodies across stages of acute HIV-1 infection
We studied the relationship between viral diversity and susceptibility to broadly neutralizing antibodies (bNAbs) in longitudinal plasma and peripheral blood mononuclear cells from 89 people with HIV who initiated antiretroviral therapy (ART) during acute and early HIV-1 infection (AEHI). HIV-1 diversity and predicted bNAb susceptibility were comparable across AEHI. Diversity evolution was not observed during ART, suggesting (pro)viruses at initiation or during treatment may identify individuals with susceptible virus for bNAb interventional trials.
Authors
- Aiyappa Parvangada
- Lisa Selzer
- Joseph J. Eron (ORCID: https://orcid.org/0000-0002-4938-0644)
- Richard Haubrich (ORCID: https://orcid.org/0000-0002-9435-2386)
- Brian Moldt (ORCID: https://orcid.org/0009-0005-8814-3202)
- John W. Mellors (ORCID: https://orcid.org/0000-0002-3737-9742)
- Laurie A. VanderVeen
- Joshua C. Cyktor (ORCID: https://orcid.org/0000-0003-3601-4837)
- Jintanat Ananworanich (ORCID: https://orcid.org/0000-0003-1369-3224)
- Trevor A. Crowell (ORCID: https://orcid.org/0000-0001-5947-265X)
- Eric S. Daar (ORCID: https://orcid.org/0000-0003-1880-7331)
- Romas Geleziunas (ORCID: https://orcid.org/0000-0002-9290-8811)
- Jiani Li (ORCID: https://orcid.org/0000-0003-3939-2542)
- Christian Callebaut (ORCID: https://orcid.org/0000-0003-4721-2572)
Institutions
- University of North Carolina at Chapel Hill (US)
Publication Details
- Journal
- UNC Libraries
- Published
- 2025-02-05
- DOI
- https://doi.org/10.17615/zr4j-dk18
- Citations
- 1
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.04
Funders
- U.S. Department of Defense
- Henry M. Jackson Foundation
- National Institutes of Health
- U.S. Army