Therapeutic Potential of Arimoclomol Nanomicelles: In Vitro Impact on Alzheimer’s and Parkinson’s Pathology and Correlation with In Vivo Inflammatory Response
This study investigates the potential of arimoclomol-loaded nanomicelles for the treatment of neurodegenerative diseases like Alzheimer's and Parkinson's, as well as their anti-inflammatory properties. Arimoclomol, a coinducer of heat shock proteins (HSPs), has shown clinical promise in mitigating protein misfolding, a hallmark of these diseases. In this work, arimoclomol nanomicelles significantly reduced the aggregation of β-amyloid (Aβ<sub>1-42</sub>) and α-synuclein (α-syn), key pathological proteins in Alzheimer's and Parkinson's. Additionally, the nanomicelles demonstrated potent anti-inflammatory effects, reducing leukocyte and neutrophil counts in an acute inflammation model. These results suggest that arimoclomol nanomicelles could enhance clinical outcomes by targeting both neurodegenerative and inflammatory processes, offering a promising therapeutic strategy for long-term disease management.
Authors
- Patrı́cia Silva (ORCID: https://orcid.org/0000-0002-6613-9000)
- Cristian Follmer (ORCID: https://orcid.org/0000-0001-6178-0432)
- Tatiana Paula Teixeira Ferreira (ORCID: https://orcid.org/0000-0003-0246-4960)
- Luciana Magalhães Rebêlo Alencar (ORCID: https://orcid.org/0000-0001-8210-2016)
- Pierre Basílio Almeida Fechine (ORCID: https://orcid.org/0000-0002-7822-2354)
- Marília Amável Gomes Soares (ORCID: https://orcid.org/0000-0003-2390-8428)
- Ralph Santos‐Oliveira (ORCID: https://orcid.org/0000-0002-0905-481X)
- Eduardo Ricci‐Júnior (ORCID: https://orcid.org/0000-0002-2550-696X)
- Natália Cristina Gomes-da-Silva (ORCID: https://orcid.org/0000-0002-9088-6671)
- Celso Sant’Anna
- Isabelle Xavier-de-Britto
- David Dabkiewicz
Institutions
- Universidade Federal do Rio de Janeiro (BR)
- Universidade Federal do Ceará (BR)
- Universidade do Estado do Rio de Janeiro (BR)
- Instituto Nacional de Metrologia, Qualidade e Tecnologia (BR)
- Faculdades Oswaldo Cruz (BR)
- Nuclear Engineering Institute (BR)
- Institute of Chemistry (CN)
- Metallopharm (United States) (US)
- Universidade Federal do Maranhão (BR)
- Fundação Oswaldo Cruz (BR)
Publication Details
- Journal
- ACS Chemical Neuroscience
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1021/acschemneuro.4c00734
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Governo Brasil
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
- Fundação Oswaldo Cruz
- Universidade do Estado do Rio de Janeiro
- Universidade Federal do Rio de Janeiro
- National Institute of Metrology, China