Hypoxia-Regulated CD44 and xCT Expression Contributes to Late Postoperative Epilepsy in Glioblastoma
Late epilepsy after GBM resection was related to extracellular Glu concentrations that were regulated by reciprocal expression of CD44 and xCT, which were stimulated by differential hypoxia for each molecule.
Authors
- Seiji Shigekawa (ORCID: https://orcid.org/0009-0005-2884-1201)
- Mohammed E. Choudhury (ORCID: https://orcid.org/0000-0002-2658-5487)
- Akihiro Inoue (ORCID: https://orcid.org/0000-0002-7438-2369)
- Daisuke Yamashita (ORCID: https://orcid.org/0000-0003-1657-8192)
- Takanori Ohnishi (ORCID: https://orcid.org/0000-0001-8777-6458)
- Hajime Yano (ORCID: https://orcid.org/0000-0002-1615-7526)
- Masahiro Nishikawa (ORCID: https://orcid.org/0000-0002-1302-7646)
- Takeharu Kunieda (ORCID: https://orcid.org/0000-0001-8653-0763)
- Kosuke Kusakabe (ORCID: https://orcid.org/0000-0002-6853-7838)
- Shirabe Matsumoto (ORCID: https://orcid.org/0000-0002-8337-8695)
- Satoshi Suehiro (ORCID: https://orcid.org/0000-0002-4274-947X)
- Hideaki Watanabe (ORCID: https://orcid.org/0000-0003-4769-8859)
- Motoki Murata (ORCID: https://orcid.org/0009-0001-2577-6783)
- Yawara Nakamura
- Yoshihiro Ohtsuka (ORCID: https://orcid.org/0000-0002-9864-8440)
Institutions
- Saiseikai Matsuyama Hospital (JP)
- Ehime University (JP)
Publication Details
- Journal
- Biomedicines
- Published
- 2025-02-05
- DOI
- https://doi.org/10.3390/biomedicines13020372
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science