Effect of 4-position pyridine ring substitution on Zn(II) complexes of 4-substituted Py <sub>2</sub> N <sub>2</sub> pyridinophane macrocycles
The metal binding properties of macrocyclic small molecules is a key property that drives what applications for which these ligands can be used. Pyridine modified Py<sub>2</sub>N<sub>2</sub> pyridinophane small molecules are a new class of macrocyclic small molecules, whose properties have not been explored. As a result, Zn(II) metal binding of a library of six pyridine modified Py<sub>2</sub>N<sub>2</sub> complexes are reported here. These results include <sup>1</sup>H NMR, log β<sub>Zn(II)</sub>, and X-ray diffraction, which are compared to PyN<sub>3</sub> congeners to show that the differences in each scaffold yield markedly different metal binding properties that can be exploited in future applications.
Authors
- Timothy M. Schwartz (ORCID: https://orcid.org/0000-0002-9070-6810)
- Katherine J. Smith (ORCID: https://orcid.org/0009-0004-5730-7342)
- Hannah M. Johnston (ORCID: https://orcid.org/0000-0002-6499-7159)
- Kristof Pota (ORCID: https://orcid.org/0000-0002-9027-0201)
- Kayla N. Green (ORCID: https://orcid.org/0000-0001-8816-7646)
- David M. Freire (ORCID: https://orcid.org/0000-0002-0976-2680)
Institutions
- Texas Christian University (US)
Publication Details
- Journal
- Journal of Coordination Chemistry
- Published
- 2025-02-03
- DOI
- https://doi.org/10.1080/00958972.2025.2453062
- Primary Topic
- Metal complexes synthesis and properties
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Welch Foundation
- National Institute of General Medical Sciences