Extracellular vimentin is a damage-associated molecular pattern protein serving as an agonist of TLR4 in human neutrophils
Our study identifies new functions of eVim in its native and modified forms as an extracellular matrix DAMP and highlights its importance in the modulation of immune system functions. The differential effects of eVim and CitVim on neutrophil functions highlight their potential as new molecular targets for therapeutic strategies aimed at regulation of neutrophil activity in different pathological conditions. This, in turn, opens new windows of therapeutic intervention in inflammatory and immunological diseases characterized by immune system dysfunction, in which eVim and CitVim play a key role.
Authors
- Magdalena Zakrzewska (ORCID: https://orcid.org/0000-0002-2756-6659)
- Krzysztof Fiedoruk (ORCID: https://orcid.org/0000-0001-7343-8837)
- Karol Skłodowski
- Peter A. Galie (ORCID: https://orcid.org/0000-0001-5161-4924)
- Agata Lesiak (ORCID: https://orcid.org/0000-0002-2953-4685)
- Łukasz Suprewicz (ORCID: https://orcid.org/0000-0001-6666-9688)
- Paul A. Janmey (ORCID: https://orcid.org/0000-0002-3495-3286)
- Alicja Walewska (ORCID: https://orcid.org/0000-0003-0610-6191)
- Alison E. Patteson
- Evan Hutt
- Sławomir Okła (ORCID: https://orcid.org/0000-0002-3906-8083)
- Piotr Deptuła (ORCID: https://orcid.org/0000-0003-3553-3774)
- Robert Bucki (ORCID: https://orcid.org/0000-0001-7664-9226)
Institutions
- Medical University of Białystok (PL)
- Jan Kochanowski University (PL)
- Rowan University (US)
- Syracuse University (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1186/s12964-025-02062-w
- Citations
- 8
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 12.98
Funders
- Fundacja na rzecz Nauki Polskiej
- Narodowe Centrum Nauki
- Uniwersytet Medyczny w Bialymstoku