PTOV1 exerts pro-oncogenic role in colorectal cancer by modulating SQSTM1-mediated autophagic degradation of p53
Our study unveils the oncogenic role of PTOV1 in CRC progression, which was achieved by promoting SQSTM1 directed autophagic degradation of p53. These findings highlight the potential of targeting the PTOV1-SQSTM1-p53 axis as a therapeutic approach for CRC.
Authors
- Yongli Fan
- Weilong Chang
- Weiwei Zhu (ORCID: https://orcid.org/0000-0003-3290-0129)
- Jie Zhan (ORCID: https://orcid.org/0000-0001-6487-344X)
- Zhibo Liu (ORCID: https://orcid.org/0000-0002-9641-3402)
- Shiqi Xiang (ORCID: https://orcid.org/0000-0002-9909-8516)
- Yingchun Cai (ORCID: https://orcid.org/0000-0002-8600-7275)
- Xia Luo
- Rui Deng (ORCID: https://orcid.org/0000-0002-6511-8662)
- Huifen Wang (ORCID: https://orcid.org/0000-0002-5888-9899)
- Yuqin Li (ORCID: https://orcid.org/0000-0001-6188-8590)
- Jia Hu (ORCID: https://orcid.org/0000-0003-2618-2079)
- Xianwen Ran
- Di Wang (ORCID: https://orcid.org/0000-0003-0117-1314)
- Yize Zhang (ORCID: https://orcid.org/0009-0009-6790-3590)
Institutions
- Central Hospital of Wuhan (CN)
- First Affiliated Hospital of Henan University (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Tongji Hospital (CN)
- Wuhan University of Science and Technology (CN)
- Huazhong University of Science and Technology (CN)
- Henan Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1186/s12967-025-06179-x
- Citations
- 1
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China
- Zhengzhou University
- Natural Science Foundation of Henan Province
- Wuhan University
- Wuhan University of Science and Technology
- First Affiliated Hospital of Zhengzhou University