Single-cell profiling reveals a reduced epithelial defense system, decreased immune responses and the immune regulatory roles of different fibroblast subpopulations in chronic atrophic gastritis
The main goal of this study was to comprehensively elucidate the cellular changes in CAG lesions. We observed an immune decline in the mucosal microenvironment during the development of CAG, including a reduced immune response of C1Q<sup>+</sup> macrophages, reduced cytotoxicity of T cells, and increased infiltration of exhausted T cells. Specifically, we demonstrated that different epithelial subtypes aberrantly express genes related to susceptibility to external bacterial infection and aberrant cell cycle progression. Our study provides new insights into the functions of epithelial changes and immune alterations during the development of CAG.
Authors
- Yizhe Wang (ORCID: https://orcid.org/0000-0002-4143-7001)
- Yujie Duan (ORCID: https://orcid.org/0000-0001-9968-4016)
- Jie Zhou (ORCID: https://orcid.org/0000-0001-5964-1599)
- Feng Chen (ORCID: https://orcid.org/0000-0001-7849-2023)
- Weimin Ye (ORCID: https://orcid.org/0000-0002-6859-4648)
- Lizhi Li (ORCID: https://orcid.org/0000-0002-3957-1025)
- Lin Yang (ORCID: https://orcid.org/0000-0003-1547-8990)
- Shiwei He (ORCID: https://orcid.org/0000-0002-1590-0656)
- Yawen An (ORCID: https://orcid.org/0009-0004-1792-1276)
- Tingxuan Huang
- Ziyi Zheng (ORCID: https://orcid.org/0009-0008-9918-6728)
- Lin Lin (ORCID: https://orcid.org/0009-0006-8310-9010)
- Weihao You
Institutions
- Fujian Medical University (CN)
- Karolinska Institutet (SE)
- Shanghai Clinical Research Center (CN)
- Union Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1186/s12967-025-06150-w
- Citations
- 4
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 8.03
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province
- Karolinska Institutet
- Fujian Medical University