16S rRNA sequencing reveals relationships among enrichment of oral microbiota in the lower respiratory tract and pulmonary nodules malignant progression
This study is the first to elucidate the composition and interrelationships of oral and lower respiratory tract (LRT) microbiota in patients with pulmonary nodule (PN) across varying malignancy risk levels. We conducted an analysis to investigate the correlation between the malignant potential of PNs and the enrichment of oral microbiota within the LRT. Additionally, we explored the feasibility of utilizing oral-lower respiratory commensal microbiota as biomarkers to assess the benign and malignant nature of pulmonary nodules. This study aims to provide evidence supporting early diagnosis and intervention strategies for lung cancer.
Authors
- Qiong Ma
- Fengming You (ORCID: https://orcid.org/0000-0001-7900-4060)
- Jierong Han (ORCID: https://orcid.org/0000-0001-8104-028X)
- Yifeng Ren (ORCID: https://orcid.org/0000-0003-2976-4250)
- Fang Li (ORCID: https://orcid.org/0000-0001-8083-4002)
- Jing Guo (ORCID: https://orcid.org/0000-0001-9861-0250)
- Jiawei He
- Xi Fu (ORCID: https://orcid.org/0000-0002-0665-6612)
Institutions
- Jining Traditional Chinese Medicine Hospital (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1128/spectrum.01284-24
- Citations
- 4
- Primary Topic
- Oral Health Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.86
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Department of Science and Technology of Sichuan Province
- Natural Science Foundation of Sichuan Province
- Natural Science Foundation for Young Scientists of Shanxi Province
- Young Scientists Fund