Integrating electrocardiogram and fundus images for early detection of cardiovascular diseases

Cardiovascular diseases (CVD) are a predominant health concern globally, emphasizing the need for advanced diagnostic techniques. In our research, we present an avant-garde methodology that synergistically integrates ECG readings and retinal fundus images to facilitate the early disease tagging as well as triaging of the CVDs in the order of disease priority. Recognizing the intricate vascular network of the retina as a reflection of the cardiovascular system, alongwith the dynamic cardiac insights from ECG, we sought to provide a holistic diagnostic perspective. Initially, a Fast Fourier Transform (FFT) was applied to both the ECG and fundus images, transforming the data into the frequency domain. Subsequently, the Earth Mover's Distance (EMD) was computed for the frequency-domain features of both modalities. These EMD values were then concatenated, forming a comprehensive feature set that was fed into a Neural Network classifier. This approach, leveraging the FFT's spectral insights and EMD's capability to capture nuanced data differences, offers a robust representation for CVD classification. Preliminary tests yielded a commendable accuracy of 84%, underscoring the potential of this combined diagnostic strategy. As we continue our research, we anticipate refining and validating the model further to enhance its clinical applicability in resource limited healthcare ecosystems prevalent across the Indian sub-continent and also the world at large.

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Publication Details

Journal
Scientific Reports
Published
2025-02-05
DOI
https://doi.org/10.1038/s41598-025-87634-z
Citations
10
Primary Topic
Retinal Imaging and Analysis
Type
article
Field-Weighted Citation Impact
13.60
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article

Integrating electrocardiogram and fundus images for early detection of cardiovascular diseases

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10 citations
Scientific Reports
Retinal Imaging and Analysis
13.60
article

Integrating electrocardiogram and fundus images for early detection of cardiovascular diseases

Dhruva Nandi, Aiswaryah Radhakrishnan, Krithika Ramachandran, K. Muthukumar, Priya Ranjan, Rajiv Janardhanan, Anirban Ghosh, Shiny PJ, M Ashwini, V.E. Dhandapani
article en
10 citations

Abstract

Cardiovascular diseases (CVD) are a predominant health concern globally, emphasizing the need for advanced diagnostic techniques. In our research, we present an avant-garde methodology that synergistically integrates ECG readings and retinal fundus images to facilitate the early disease tagging as well as triaging of the CVDs in the order of disease priority. Recognizing the intricate vascular network of the retina as a reflection of the cardiovascular system, alongwith the dynamic cardiac insights from ECG, we sought to provide a holistic diagnostic perspective. Initially, a Fast Fourier Transform (FFT) was applied to both the ECG and fundus images, transforming the data into the frequency domain. Subsequently, the Earth Mover's Distance (EMD) was computed for the frequency-domain features of both modalities. These EMD values were then concatenated, forming a comprehensive feature set that was fed into a Neural Network classifier. This approach, leveraging the FFT's spectral insights and EMD's capability to capture nuanced data differences, offers a robust representation for CVD classification. Preliminary tests yielded a commendable accuracy of 84%, underscoring the potential of this combined diagnostic strategy. As we continue our research, we anticipate refining and validating the model further to enhance its clinical applicability in resource limited healthcare ecosystems prevalent across the Indian sub-continent and also the world at large.

Scientific ReportsVol. 15(1)
SRM Institute of Science and Technology (IN), SRM University, Andhra Pradesh (IN), TCG Crest (IN), University of Petroleum and Energy Studies (IN)
Openalex Percentile: Top 1%
Retinal Imaging and Analysis
13.60
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