Amyloids in bladder cancer hijack cancer-related proteins and are positive correlated to tumor stage
Despite the current diagnostic and therapeutic approaches to bladder cancer being widely accepted, there have been few significant advancements in this field over the past decades. This underscores the necessity for a paradigm shift in the approach to bladder cancer. The role of amyloids in cancer remains unclear despite their identification in several other pathologies. In this study, we present evidence of amyloids in bladder cancer, both in vitro and in vivo. In a murine model of bladder cancer, a positive correlation was observed between amyloids and tumor stage, indicating an association between amyloids and bladder cancer progression. Subsequently, the amyloid proteome of the RT4 non-invasive and HT1197 invasive bladder cancer cell lines was identified and included oncogenes, tumor suppressors, and highly expressed cancer-related proteins. It is proposed that amyloids function as structures that sequester key proteins. Therefore, amyloids should be considered in the study and diagnosis of bladder cancer.
Authors
- Carolina Villadóniga (ORCID: https://orcid.org/0000-0001-5728-7370)
- Susana Castro‐Sowinski (ORCID: https://orcid.org/0000-0002-1286-1743)
- Federico Carrión (ORCID: https://orcid.org/0000-0003-4092-2168)
- Joaquina Farías (ORCID: https://orcid.org/0000-0003-2167-9123)
- Dardo Centurión (ORCID: https://orcid.org/0000-0002-2343-3816)
- Diego Alem (ORCID: https://orcid.org/0000-0002-0279-8226)
- Martín Fló (ORCID: https://orcid.org/0000-0002-6514-4270)
- Lucía Canclini (ORCID: https://orcid.org/0000-0001-7421-611X)
- César X. García-Laviña
- Kevin P. Madauss
- Brenda Iglesias (ORCID: https://orcid.org/0000-0002-7158-7975)
- Francisco Garagorry
- Hany Pazos-Espinosa
- María Noel Cuitiño-Mendiberry
Institutions
- Boston University (US)
- Universidad de la República de Uruguay (UY)
- Hospital de Clínicas (UY)
- Institut Pasteur de Montevideo (UY)
- Instituto de Investigaciones Biológicas Clemente Estable (UY)
Publication Details
- Journal
- Scientific Reports
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1038/s41598-025-88307-7
- Citations
- 1
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Agencia Nacional de Investigación e Innovación
- Agencia Nacional de Investigación y Desarrollo