Gut microbiota and OMVs: Unveiling novel regulatory mechanisms in high‐altitude myocardial injury
The gut microbiota influences host health, with outer membrane vesicles (OMVs) facilitating intercellular communication and transporting bioactive molecules. At high altitudes, OMVs can cross the intestinal barrier, affecting heart function and potentially modulating inflammation, oxidative stress, and apoptosis in cardiomyocytes. Genetic engineering of OMVs may improve their therapeutic efficacy by altering surface properties to enhance targeting and residence time. They could also act as disease biomarker carriers for early detection and monitoring.
Authors
- Mingyang Chang (ORCID: https://orcid.org/0009-0000-3087-5279)
- Zhexin Ni (ORCID: https://orcid.org/0000-0002-9723-2398)
- Dianjianyi Sun (ORCID: https://orcid.org/0000-0003-3651-6693)
- Pan Shen (ORCID: https://orcid.org/0000-0003-3374-0382)
- Zhijie Bai (ORCID: https://orcid.org/0000-0003-2231-1320)
- Tiantian Xia
- Wei Zhou (ORCID: https://orcid.org/0000-0003-0435-7261)
- Shuman Li
- Chaoji Huangfu (ORCID: https://orcid.org/0000-0002-8650-7149)
- Yangyi Hu (ORCID: https://orcid.org/0009-0001-0441-0571)
- Yue Gao (ORCID: https://orcid.org/0009-0007-1478-7464)
- Ningning Wang (ORCID: https://orcid.org/0009-0006-8874-4662)
- Yongqiang Zhou (ORCID: https://orcid.org/0000-0003-1402-345X)
Institutions
- Qinghai University (CN)
- Chinese PLA General Hospital (CN)
- First Teaching Hospital of Tianjin University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- iMetaOmics.
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1002/imo2.70001
- Citations
- 1
- Primary Topic
- Cardiac Arrest and Resuscitation
- Type
- article
- Field-Weighted Citation Impact
- 2.25