Promising role of Fecal microbiota transplantation in Stroke management

Stroke, a cerebro-vascular disease presents a major global health problem, rated as the world's second-leading cause of death and the third most common cause of disability. Although in recent years there have been remarkable achievements in prevention, treatment, and recovery of post-stroke complications still, there is not a definite solution to overcome for this global problem. Differential transcription of certain gene segments are implicated in the location of stroke, which imbalances the proteome. Protein IL-1β anticipated to be the main culprit for the epigenetic modifications. Link between faecal microbiota transplantation (FMT) and Stroke management has been tried in rat model which gave promising results. In the recent past, several studies have indicated the key role of the gut microbiota composition and its alterations in the pathophysiology of stroke similar to many other diseases. In the present review, the alteration of gut microbiota due to the disease as well as dysbiosis of the microbiota as a causal factor for the development of the disease is discussed. The results of FMT trials in animal models and few human trials are summarised.