Edaravone dexborneol alleviates pericyte-mediated fibrosis depositing extracellular matrix through TGF-β1/IL-11 in cerebral small vessel disease
Our findings reveal the role of pericyte-mediated fibrosis in depositing ECM in the pathogenesis of CSVD. EDB could improve symptoms and the underlying pathogenesis of CCH mice and decrease the expression of the fibrous profiles of pericytes and ECM proteins, which may be regulated by TGF-β1/ IL-11. EDB treatment, targeting pericytes fibrosis, may be a novel therapeutic strategy for CSVD.
Authors
- Qingrui Duan
- Haifeng Huang (ORCID: https://orcid.org/0000-0003-1478-0303)
- Yuyuan Gao (ORCID: https://orcid.org/0000-0002-0713-8008)
- Guixian Ma (ORCID: https://orcid.org/0009-0002-9018-2671)
- Jiaxuan Liu (ORCID: https://orcid.org/0000-0002-8955-5832)
- HE Pei-kun
- Yuhu Zhang (ORCID: https://orcid.org/0000-0003-3492-4669)
- Yu-Xuan Xing
- Lijuan Wang (ORCID: https://orcid.org/0000-0002-1288-155X)
- Zhiyang Liu (ORCID: https://orcid.org/0000-0003-4985-9214)
- Lin Zhu (ORCID: https://orcid.org/0000-0002-6331-9444)
- Kun Nie (ORCID: https://orcid.org/0000-0001-6427-2660)
Institutions
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1186/s12967-025-06157-3
- Citations
- 3
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.53
Funders
- National Natural Science Foundation of China
- Guangdong Provincial Key Laboratory for Translational Cancer Research of Chinese Medicine, Guangzhou University of Chinese Medicine
- Science and Technology Planning Project of Guangdong Province
- National Science and Technology Planning Project
- Basic and Applied Basic Research Foundation of Guangdong Province