Development and evaluation of a novel E7 multi-epitopic vaccine for human papillomavirus type 16: design, expression, purification, and immunological characterization
The poly-epitope vaccine for HPV16-E7, as expressed and purified in this research, is highly immunogenic and capable of triggering E7-specific antibodies, making it a potential therapeutic HPV vaccine. Further research is needed to optimize the vaccination schedule and assess the E7-specific immune cell profile.
Authors
- Bahareh Bahmani (ORCID: https://orcid.org/0000-0001-6966-6685)
- Masoud Hassanzadeh Makoui (ORCID: https://orcid.org/0000-0002-0821-4420)
- Amir‐Hassan Zarnani (ORCID: https://orcid.org/0000-0003-4503-299X)
- Zahra Amini-Bayat
- Mohammad Mehdi Ranjbar (ORCID: https://orcid.org/0000-0001-8611-5762)
Institutions
- Zanjan University of Medical Sciences (IR)
- Razi Vaccine and Serum Research Institute (IR)
- Iran University of Medical Sciences (IR)
- Royan Institute (IR)
- Iranian Research Organization for Science and Technology (IR)
- Academic Center for Education, Culture and Research (IR)
- Agricultural Research & Education Organization (IR)
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- BMC Infectious Diseases
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1186/s12879-024-10343-x
- Citations
- 3
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- Iran University of Medical Sciences
- Iranian Research Organization for Science and Technology