Age-related changes in DNA methylation in a sample of elderly Brazilians
This longitudinal study identified age-associated and timepoint-associated DMPs and DMRs in a sample of elderly Brazilians. Most of the non-replicated CpGs were found to be on the new EPIC array, suggesting that more age-related studies using the EPIC array are required to validate these CpGs. The GO pathway enrichment analyses identified age-related enrichment of several gene sets related to cognitive and physical decline in elderly populations. The enrichment of these sites could provide evidence for age-related neurodegeneration and cognitive decline in elderly populations.
Authors
- Esteban J. Parra (ORCID: https://orcid.org/0000-0002-2057-8577)
- Yeda A. O. Duarte (ORCID: https://orcid.org/0000-0003-3933-2179)
- H. L. Welsh
- Nadja C. de Souza‐Pinto (ORCID: https://orcid.org/0000-0003-4206-964X)
- Caio M.P.F. Batalha
- Michel Satya Naslavsky (ORCID: https://orcid.org/0000-0002-9068-1713)
- Weili Li (ORCID: https://orcid.org/0000-0003-4316-9642)
Institutions
- Hatch (Canada) (CA)
- Universidade de São Paulo (BR)
- University of Toronto (CA)
- Hospital for Sick Children (CA)
- SickKids Foundation (CA)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1186/s13148-025-01821-3
- Citations
- 7
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 5.64
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- University of Toronto
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Hospital for Sick Children
- Natural Sciences and Engineering Research Council of Canada