Liver macrophage-derived exosomal miRNA-342-3p promotes liver fibrosis by inhibiting HPCAL1 in stellate cells
This study reveals a previously unidentified profibrotic mechanism of crosstalk between macrophages and HSCs in the liver and suggests an attractive novel therapeutic strategy for treating fibroproliferative liver diseases.
Authors
- Zhongguang Luo (ORCID: https://orcid.org/0000-0002-7620-307X)
- Wanwei Zheng (ORCID: https://orcid.org/0000-0002-3916-7348)
- Tiansheng Huang (ORCID: https://orcid.org/0000-0002-4557-1865)
- Jun Zhang (ORCID: https://orcid.org/0000-0002-9330-6070)
- Jie Liu (ORCID: https://orcid.org/0000-0002-9792-5127)
- Qi Zhou (ORCID: https://orcid.org/0000-0002-6549-9362)
- Wenshuai Li (ORCID: https://orcid.org/0000-0002-1322-2994)
- Fei‐Fei Luo (ORCID: https://orcid.org/0000-0002-6543-0023)
- Lirong Chen (ORCID: https://orcid.org/0000-0002-0333-4490)
Institutions
- Fudan University (CN)
- Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- Human Genomics
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1186/s40246-025-00722-z
- Citations
- 4
- Primary Topic
- Liver Disease and Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 5.29
Funders
- National Natural Science Foundation of China