Autism spectrum disorder common variants associated with regional lobe volume variations at birth: cross-sectional study in 273 European term neonates in developing human connectome project
Increasing lines of evidence suggest cerebral overgrowth in autism spectrum disorder (ASD) children in early life, but few studies have examined the effect of ASD common genetic variants on brain volumes in a general paediatric population. This study examined the association between ASD polygenic risk score (PRS) and volumes of the frontal, temporal, parietal, occipital, fronto-temporal and parieto-occipital lobes in 273 term-born infants of European ancestry in the developing Human Connectome Project. ASD PRS was positively associated with frontal (β = 0.027, p<sub>FDR</sub> = 0.04) and fronto-temporal (β = 0.024, p<sub>FDR</sub> = 0.01) volumes, but negatively with parietal (β = -0.037, p<sub>FDR</sub> = 0.04) and parieto-occipital (β = -0.033, p<sub>FDR</sub> = 0.01) volumes. This preliminary result suggests the potential involvement of ASD common genetic variants in early structural variations linked to ASD.
Authors
- A. David Edwards (ORCID: https://orcid.org/0000-0003-4801-7066)
- Lucilio Cordero‐Grande (ORCID: https://orcid.org/0000-0003-1477-304X)
- Jacques‐Donald Tournier (ORCID: https://orcid.org/0000-0001-5591-7383)
- Maria Deprez (ORCID: https://orcid.org/0000-0002-2799-6077)
- Charles Curtis (ORCID: https://orcid.org/0000-0002-2992-1941)
- Hamel Patel (ORCID: https://orcid.org/0000-0001-7951-6728)
- Daphna Fenchel (ORCID: https://orcid.org/0009-0005-2352-4186)
- Harriet Cullen (ORCID: https://orcid.org/0000-0002-2846-1621)
- Joseph V. Hajnal (ORCID: https://orcid.org/0000-0002-2690-5495)
- Konstantina Dimitrakopoulou (ORCID: https://orcid.org/0000-0001-7159-0093)
- Hai Le (ORCID: https://orcid.org/0000-0001-6221-6980)
Institutions
- King's College London (GB)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- South London and Maudsley NHS Foundation Trust (GB)
- Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (ES)
- Universidad Politécnica de Madrid (ES)
Publication Details
- Journal
- Translational Psychiatry
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1038/s41398-025-03253-2
- Citations
- 3
- Primary Topic
- Fetal and Pediatric Neurological Disorders
- Type
- article
- Field-Weighted Citation Impact
- 10.48
Funders
- Comunidad de Madrid
- National Institute for Health and Care Research
- King's College London
- Medical Research Council
- Engineering and Physical Sciences Research Council
- Menzies Centre for Australian Studies, King's College London, University of London
- Centre For Medical Engineering, King’s College London