Regional hippocampal thinning and gyrification abnormalities and associated cognition in children with prenatal alcohol exposure
We used a novel MRI method to evaluate hippocampal structure in children with PAE and an unexposed comparison group. The data suggest that PAE disrupts hippocampal development, impacting both the early-stage folding of the structure and its ultimate thickness. The data also demonstrate that these developmental anomalies have functional consequences in terms of core memory functions as well as global intellectual functioning in children with PAE.
Authors
- Blake A. Gimbel (ORCID: https://orcid.org/0000-0002-0414-0823)
- Abigail M. Ernst (ORCID: https://orcid.org/0000-0002-0868-6145)
- Mary E. Anthony
- Bryon A. Mueller (ORCID: https://orcid.org/0000-0003-2429-0391)
- Erik de Water
- Jeffrey R. Wozniak (ORCID: https://orcid.org/0000-0002-7132-8519)
- Kent A. Tuominen
Institutions
- University of Minnesota (US)
- Nationwide Children's Hospital (US)
- Twin Cities Orthopedics (US)
- The Ohio State University (US)
Publication Details
- Journal
- Journal of Neurodevelopmental Disorders
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1186/s11689-025-09595-8
- Citations
- 3
- Primary Topic
- Prenatal Substance Exposure Effects
- Type
- article
- Field-Weighted Citation Impact
- 10.48
Funders
- National Institute on Alcohol Abuse and Alcoholism