Selective disruption of Traf1/cIAP2 interaction attenuates inflammatory responses and rheumatoid arthritis
These findings reveal a previously unrecognized and crucial role for the TRAF1/cIAP2 axis in promoting inflammation and offer a promising foundation for the development of novel therapeutic strategies for inflammatory conditions, such as RA.
Authors
- Safoura Zangiabadi
- Ali A. Abdul‐Sater (ORCID: https://orcid.org/0000-0002-0022-0930)
- Robert D. Inman (ORCID: https://orcid.org/0000-0002-4750-1422)
- Gary Sweeney (ORCID: https://orcid.org/0000-0002-1946-1347)
- Fatemah Aleithan
- Ali Mirzaesmaeili (ORCID: https://orcid.org/0000-0002-3169-5066)
- Sahib Singh Madahar
- Jialing Tang (ORCID: https://orcid.org/0000-0001-5031-8031)
- Sunpreet Saran
- Yitian Tang
Institutions
- University Health Network (CA)
- York University (CA)
Publication Details
- Journal
- Journal of Autoimmunity
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1016/j.jaut.2025.103377
- Citations
- 8
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 6.45
Funders
- Banting Research Foundation
- Institute of Infection and Immunity
- Canadian Arthritis Network