Neutrophil extracellular traps-induced pyroptosis of liver sinusoidal endothelial cells exacerbates intrahepatic coagulation in cholestatic mice
NETs-induced LSECs pyroptosis exacerbates intrahepatic coagulation in cholestasis. Targeting NETs and LSECs pyroptosis holds promise for treating chronic liver injury in CLD.
Authors
- Chuwei Zheng
- Xiaolan Hu (ORCID: https://orcid.org/0000-0003-2980-4806)
- Jinming Zhang (ORCID: https://orcid.org/0000-0001-7400-4643)
- Xiaowen Li (ORCID: https://orcid.org/0000-0001-9362-4274)
- Xia Ji (ORCID: https://orcid.org/0000-0001-9730-7030)
- Xiaoguang Wang (ORCID: https://orcid.org/0000-0003-0118-4772)
- Muxin Yu
Institutions
- Jiaxing University (CN)
- First Hospital of Jiaxing (CN)
Publication Details
- Journal
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1016/j.bbadis.2025.167700
- Citations
- 6
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 4.78
Funders
- National Natural Science Foundation of China
- Science and Technology Bureau of Jiaxing City
- Medical Science and Technology Project of Zhejiang Province
- Natural Science Foundation of Zhejiang Province