Gentiopicroside alleviates neuroinflammation in Parkinson's disease by mediating microglial pyroptosis via the NF-κB/NLRP3/GSDMD pathway.
GPS exhibits neuroprotective effects in PD by suppressing microglia-mediated neuroinflammation and pyroptosis, suggesting its potential as a favorable therapeutic agent for PD treatment.
Authors
- Hong Shen
- Hui Song (ORCID: https://orcid.org/0000-0001-9526-126X)
- Qiang Sun (ORCID: https://orcid.org/0000-0002-1050-5067)
Institutions
- Hubei University of Medicine (CN)
- Wujiang District People's Hospital (CN)
- Suzhou Traditional Chinese Medicine Hospital (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-09-01
- DOI
- https://doi.org/10.14670/hh-18-879
- Citations
- 1
- Primary Topic
- Phytochemistry and Biological Activities
- Type
- article
- Field-Weighted Citation Impact
- 1.75