Grapefruit Peel-derived 5,7- Dimethoxycoumarin Enhances Insulin Release and Stimulates Extrapancreatic Secretion of Amylin in Wistar Rats.

5,7-dimethoxycoumarin will find special applications in the management of obesity and for people with diabetes having chronic complications. Since the overall plasma glucose regulation is achieved through amylin and insulin synergy, attention should be shifted from insulin-based to amylin-based therapy. There is a need to focus on natural compounds that stimulate extrapancreatic amylin release, especially in patients with type 1 diabetes who are insulin dependent.