Autonomous Epinephrine Release by KCNJ5 Mutation Drives Familial Thoracic Aortic Aneurysm and Dissection

Familial TAAD may stem from <i>KCNJ5</i> dysfunction in the G-protein-coupling domain, causing isolated systolic hypertension via increased epinephrine secretion and disruption of thoracic aortic homeostasis. These findings establish a genetic link between systolic hypertension and TAAD.

Authors

Zhenghong Lai
Nianping Hu (ORCID: https://orcid.org/0000-0002-0938-2207)
Yanyu Duan (ORCID: https://orcid.org/0000-0001-6603-3508)
Shaoqiang Liu
Qunxing Yuan
Chenglong Wu (ORCID: https://orcid.org/0000-0001-6008-999X)
Ziyou Liu (ORCID: https://orcid.org/0000-0003-4697-2684)

Institutions

Gannan Medical University (CN)
First Affiliated Hospital of Gannan Medical University (CN)

Publication Details

Journal: Hypertension
Published: 2025-02-05
DOI: https://doi.org/10.1161/hypertensionaha.124.23795
Citations: 1
Primary Topic: Aortic aneurysm repair treatments
Type: article
Field-Weighted Citation Impact: 1.52

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article

Autonomous Epinephrine Release by KCNJ5 Mutation Drives Familial Thoracic Aortic Aneurysm and Dissection

Zhenghong Lai, Nianping Hu, Yanyu Duan, Shaoqiang Liu et al.

Feb 5, 2025

1 citations

Hypertension

Aortic aneurysm repair treatments

1.52

article

Autonomous Epinephrine Release by KCNJ5 Mutation Drives Familial Thoracic Aortic Aneurysm and Dissection

Zhenghong Lai, Nianping Hu, Yanyu Duan, Shaoqiang Liu, Qunxing Yuan, Chenglong Wu, Ziyou Liu

February 5, 2025article en

1 citations

Abstract

Familial TAAD may stem from <i>KCNJ5</i> dysfunction in the G-protein-coupling domain, causing isolated systolic hypertension via increased epinephrine secretion and disruption of thoracic aortic homeostasis. These findings establish a genetic link between systolic hypertension and TAAD.

HypertensionVol. 82(4)

Gannan Medical University (CN), First Affiliated Hospital of Gannan Medical University (CN)

Life in Land

Openalex Percentile: Top 22%

Aortic aneurysm repair treatments

1.52

DOI Source OpenAlex

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Autonomous Epinephrine Release by KCNJ5 Mutation Drives Familial Thoracic Aortic Aneurysm and Dissection — Zhenghong Lai, Nianping Hu, et al. · Hypertension (2025) | TGRS Research Map | TGRS