Downregulated PSME3 Contributes to Severe Preeclampsia by Promoting Trophoblast Cell Apoptosis
In sPE placentas, hypoxia of the placenta may lead to the transcriptional inhibition of PSME3. PSME3 deficiency promotes the accumulation of UBE2V2, thereby inducing trophoblast cell apoptosis. Our study provides a new perspective for elucidating the pathogenesis of sPE.
Authors
- Xiao‐ming Ge (ORCID: https://orcid.org/0000-0002-8547-0487)
- Longying Tang
- Zaijun Lin (ORCID: https://orcid.org/0000-0002-7108-1528)
- LIN LIU (ORCID: https://orcid.org/0000-0003-3803-9173)
- Renfei Wu (ORCID: https://orcid.org/0000-0002-8847-7254)
- Chen Yang (ORCID: https://orcid.org/0000-0002-4841-9412)
- Siyuan Cao (ORCID: https://orcid.org/0000-0001-6947-6793)
- Lei Li (ORCID: https://orcid.org/0000-0002-3114-1653)
- Qiongyao Wang (ORCID: https://orcid.org/0009-0008-7384-4147)
- Hui Chen (ORCID: https://orcid.org/0000-0001-5684-6628)
- Qiujing Guan (ORCID: https://orcid.org/0009-0005-8366-1318)
Institutions
- Chongqing Normal University (CN)
- University of Shanghai for Science and Technology (CN)
- Fudan University (CN)
- Shanghai Changning Maternity and Infant Health Hospital (CN)
- Shanghai Ninth People's Hospital (CN)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
- East China Normal University (CN)
Publication Details
- Journal
- Hypertension
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1161/hypertensionaha.124.22718
- Citations
- 4
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 8.23