Gene Expression Signatures of Immaturity, Decreased <scp>pH</scp>, and Neural Hyperexcitation in the Hippocampus of Alzheimer's Disease Model Mice

These findings suggest that pathophysiological changes related to maturity, pH, and neural hyperexcitation play varying roles across individual AD model mice. Our recent study found a negative correlation between disease progression and actual pH levels in human AD patients. Considering the results presented in this study, maturity and neural hyperexcitation, which are correlated with pH, may also be linked to disease progression. Thus, gene expression changes in these factors could be useful markers for assessing the pathology in AD models.