The Impact of Musa acuminata Sap on Leptin and Adiponectin Concentration in High Fat Diet Induced Obesity on the Offspring of Wistar Rat

Background and Aim: The prevalence of obesity and its associated metabolic disorders is a significant global health challenge, necessitating the exploration of novel therapeutic strategies to improve the health and wellbeing of individuals battling this ill health. This study investigated the impact of Musa acuminata sap (MAS) on serum leptin and adiponectin concentration and overall body weight of Wistar rats subjected to High Fat Diet (HFD) induced obesity and also on the offspring of the experimental group. Methods: A total of 50 Wistar rats were procured of which group A-served as the normal control and received rats chow and water ad libitum, Group B=Obesed+pregnant untreated and were all fed with normal rat chow and water ad libitium. Groups C, D, E, F, G and H of five rats each were obese and were selected and divided into the five groups viz; Group C- obese without treatment, Group D-obese+100 mg/kg MAS, Group E-obese+200 mg/kg of MAS, Group F-obese+pregnant+100 mg/kg of MAS, Group G-obese+pregnant+200 mg/kg of MAS and Group H-obese+pregnant+1.2 mg/kg of Xenical IP. Induction of pregnancy was carried out and varying doses of MAS and standard drug Xenical IP was administered for another period of 4 weeks and their effects were analyzed. Data for body weights, concentration of serum leptin and adiponectin were collected and analyzed. Post-partum, body weight and length of offspring were also measured and recorded. Data from experimental and control groups were evaluated and compared to determine differences in the various groups. Results: Musa acuminata sap had statistical p<0.05 significant decrease in body weight and serum leptin concentration while increasing serum adiponectin concentration compared to the normal control. Conclusion: These findings suggest that Musa acuminata sap possesses potential anti-obesity properties possibly through modulation the of leptin and adiponectin concentration, highlighting it as a possible therapeutic agent for the management of obesity and metabolic disorders. Therefore, Public awareness should also be made and encouraged to help people prevent and manage obesity.