Melatonin Ameliorates Age‐Related Sarcopenia via the Gut–Muscle Axis Mediated by Serum Lipopolysaccharide and Metabolites
Our study revealed functional insights and a putative causality for the role of the gut-muscle axis in the mechanism of melatonin ameliorating age-related sarcopenia, namely, inhibition of the LPS-induced Tnfrsf12a/caspase-8 signalling pathway or serum metabolites as intermediates in the gut-muscle axis.
Authors
- Xin Xia
- Min Liu (ORCID: https://orcid.org/0000-0001-6260-0480)
- Lingshan Zhou (ORCID: https://orcid.org/0000-0002-0095-3376)
- Shi‐Xiong Liu
- Lingjie Xu (ORCID: https://orcid.org/0000-0003-4330-1535)
- Haiyan Zhang (ORCID: https://orcid.org/0000-0002-2877-2040)
- Yuan Yang (ORCID: https://orcid.org/0000-0002-9206-0312)
- Rong Liu (ORCID: https://orcid.org/0000-0003-3649-0788)
- Changjiang Liu (ORCID: https://orcid.org/0000-0002-2780-9980)
- Junping Liu (ORCID: https://orcid.org/0000-0001-7442-2116)
- Qian Xiao (ORCID: https://orcid.org/0000-0002-4515-0219)
- Li Mou
- Xiao‐Jun Ao
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Population and Family Planning Science and Technology Research Institute (CN)
- First Affiliated Hospital of University of South China (CN)
- National Center for Geriatrics and Gerontology (JP)
- First Hospital of Lanzhou University (CN)
- Lanzhou University (CN)
- Chongqing Medical University (CN)
- University of South China (CN)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/jcsm.13722
- Citations
- 11
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 12.81
Funders
- Centre Scientifique et Technique du Bâtiment