Comprehensive genomic and transcriptomic profiling of pulmonary nodules in synchronous multiple primary lung cancer
This study validated molecular distinctions between samples from major and minor nodules in patients with sMPLC at both genomic and transcriptomic levels. The major nodules exhibited heightened activity in tumor cell proliferation pathways and demonstrated malignancy-related biological characteristics, which correlated with pathological assessment results.
Authors
- Baodong Liu (ORCID: https://orcid.org/0000-0003-4364-9478)
- Lei Su (ORCID: https://orcid.org/0000-0001-5342-1552)
- Xingsheng Liu (ORCID: https://orcid.org/0000-0002-8815-7752)
- Peilong Zhang
- Tengteng Wang (ORCID: https://orcid.org/0000-0001-9001-186X)
- Ruotian Wang
- Zhenzhen Li (ORCID: https://orcid.org/0000-0002-7035-6657)
- Han Li (ORCID: https://orcid.org/0000-0002-5755-2880)
- Yuanbo Li (ORCID: https://orcid.org/0009-0005-6708-7002)
- Xin Zhao (ORCID: https://orcid.org/0000-0003-2860-5899)
- Kun Qian (ORCID: https://orcid.org/0000-0003-1666-1965)
- Xiaoru Tian
- Yi Zhang (ORCID: https://orcid.org/0000-0001-6881-384X)
- Xiaogang Tan
Institutions
- Capital Medical University (CN)
- Viva Biotech (China) (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1186/s40001-025-02327-7
- Citations
- 1
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Capital Health Research and Development of Special Fund