Nicotinamide Phosphoribosyltransferase Acetylation Mediating Muscle Dysfunction Contributes to Sleep Apnoea in Obesity
These findings highlight the crucial role of SIRT1-mediated NAMPT deacetylation on obesity-induced muscle dysfunction, suggesting targeting NAMPT has the potential to reverse the obesity induced muscle dysfunction and provide effective treatment options for OSA.
Authors
- Shi Qi Li (ORCID: https://orcid.org/0000-0002-7172-5725)
- Li Yue Zhang
- Yu Qing Wang
- Qing Yun Li (ORCID: https://orcid.org/0000-0001-8128-6319)
- Yong Ding (ORCID: https://orcid.org/0000-0001-8766-3381)
- Fang Lu
- Liu Zhang (ORCID: https://orcid.org/0000-0003-3721-0071)
- Ning Li (ORCID: https://orcid.org/0000-0002-6518-2541)
- Yi Wang (ORCID: https://orcid.org/0000-0002-0921-1731)
- Ya Ru Yan
- Jian Zhou (ORCID: https://orcid.org/0000-0002-0147-4940)
- Xian Wen Sun (ORCID: https://orcid.org/0000-0001-8108-4629)
- Ying Ni Lin (ORCID: https://orcid.org/0000-0002-6761-5072)
Institutions
- Albert Einstein College of Medicine (US)
- Montefiore Medical Center (US)
- Shanghai Jiao Tong University (CN)
- Ruijin Hospital (CN)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/jcsm.13693
- Citations
- 1
- Primary Topic
- Obstructive Sleep Apnea Research
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- National Natural Science Foundation of China