Exploring the effects of adolescent social isolation stress on the serotonin system and ethanol-motivated behaviors
Our results highlight an inverse relationship between EtOH consumption and the 5-HT system, the sex- and stress-dependent nature of this relationship, and a connection between DRN 5-HT signaling and acute responding to rewards and punishment. These data support the DRN 5-HT system as a potential target to treat aberrant alcohol consumption and drinking despite negative consequences in stress-vulnerable populations.
Authors
- Lynn G. Kirby (ORCID: https://orcid.org/0000-0001-5684-6716)
- Bryan D. McElroy
- Antonella Alberici (ORCID: https://orcid.org/0000-0001-7137-717X)
- Nicholas McCloskey
- Chen Li (ORCID: https://orcid.org/0000-0001-5385-6249)
Institutions
- Temple University (US)
Publication Details
- Journal
- Psychopharmacology
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1007/s00213-025-06749-3
- Citations
- 3
- Primary Topic
- Neurotransmitter Receptor Influence on Behavior
- Type
- article
- Field-Weighted Citation Impact
- 2.73
Funders
- University of Manitoba
- Temple University
- National Institute on Alcohol Abuse and Alcoholism
- National Institute on Drug Abuse