Microbiota governs host chenodeoxycholic acid glucuronidation to ameliorate bile acid disorder induced diarrhea
These findings uncover the crucial interplay between gut epithelial cells and microbes, highlighting UGT1A4-mediated conversion of CDCA-3β-glucuronide as a key target for ameliorating BA disorder-induced diarrhea. Video Abstract.
Authors
- Xi Ma (ORCID: https://orcid.org/0000-0003-4562-9331)
- Zishen Lin (ORCID: https://orcid.org/0000-0001-6371-1211)
- Zhaoyue Men
- Jinping Wang (ORCID: https://orcid.org/0000-0003-2642-2132)
- Yue Feng
Institutions
- China Agricultural University (CN)
Publication Details
- Journal
- Microbiome
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1186/s40168-024-02011-8
- Citations
- 11
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 19.92