Effects of Shenmai Injection on the Pharmacokinetics of Dasatinib: An In-Depth In vivo Analysis Utilizing UPLC-MS/MS Technique
The study revealed that Shenmai injection might have the capacity to slow down the absorption rate of dasatinib and could extend the retention period of dasatinib in the body, resulting in stabilized blood drug concentrations and a reduction in adverse drug reactions.
Authors
- Lei Lv (ORCID: https://orcid.org/0000-0001-5850-3397)
- Ling Li (ORCID: https://orcid.org/0000-0002-2046-3462)
- Zhihui Li (ORCID: https://orcid.org/0000-0001-5356-932X)
- Yifei Zhu (ORCID: https://orcid.org/0000-0002-7756-2103)
- Weina Ma (ORCID: https://orcid.org/0000-0001-9565-8494)
- Rong Wang (ORCID: https://orcid.org/0000-0001-9161-9543)
- Jungang Guo
- Liye Ge
Institutions
- Shanghai University (CN)
- Second Military Medical University (CN)
- Jiading District Central Hospital (CN)
- Shanghai Ninth People's Hospital (CN)
- Eastern Hepatobiliary Surgery Hospital (CN)
Publication Details
- Journal
- Current Drug Metabolism
- Published
- 2025-02-04
- DOI
- https://doi.org/10.2174/0113892002336775250108112738
- Citations
- 1
- Primary Topic
- Chronic Myeloid Leukemia Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.77